selective mc4r antagonists Search Results


ly2112688 melanocortin-4 receptor (mc4r) peptide agonist  (Bachem)
90
Bachem ly2112688 melanocortin-4 receptor (mc4r) peptide agonist
GLP-1 secretagogues.
Ly2112688 Melanocortin 4 Receptor (Mc4r) Peptide Agonist, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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GLP-1 secretagogues.

Journal: Molecular Metabolism

Article Title: Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

doi: 10.1016/j.molmet.2020.100990

Figure Lengend Snippet: GLP-1 secretagogues.

Article Snippet: LY2112688 , Melanocortin-4 receptor (MC4R) peptide agonist , Intraperitoneal , PBS , 3 mg/kg , Bachem (819048-44-7).

Techniques:

Distal gut Gcg expression is required for acute GPR119- and MC4R-stimulated increases in plasma GLP-1. Gcg DistalGut+/+ and Gcg DistalGut−/- mice were treated with either an oral gavage of the GPR119 agonist, AR231453 (10 mg/kg BW), vehicle alone, or an intraperitoneal injection of the MC4R agonist, LY2112688 (3 mg/kg BW), at time zero. Blood glucose and total GLP-1 (tGLP-1) were measured at the indicated time points. ( A, B) Time course of blood glucose levels during AR231453 stimulus and corresponding AUC analysis. ( C, D) Time course of total tGLP-1 levels during AR231453 stimulus and corresponding AUC analysis. ( E, F) Time course of blood glucose levels during LY2112688 stimulus and corresponding AUC analysis. ( G, H) Time course of total tGLP-1 levels during LY2112688 stimulus and corresponding AUC analysis. For AR231453 studies: Gcg DistalGut+/+ AR231453, n = 14 (males + females); Gcg DistalGut+/+ Vehicle, n = 5 (males + females); Gcg DistalGut−/- AR231453, n = 5 (males + females). For LY2112688 studies: Gcg DistalGut+/+ , n = 19 (males + females); Gcg DistalGut−/- , n = 5 (males + females). Statistical significance was determined using one-way ANOVA (panels B, D) or two-tailed t -test (panels F, H). ∗∗ P < 0.01; ∗∗∗ P < 0.001.

Journal: Molecular Metabolism

Article Title: Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

doi: 10.1016/j.molmet.2020.100990

Figure Lengend Snippet: Distal gut Gcg expression is required for acute GPR119- and MC4R-stimulated increases in plasma GLP-1. Gcg DistalGut+/+ and Gcg DistalGut−/- mice were treated with either an oral gavage of the GPR119 agonist, AR231453 (10 mg/kg BW), vehicle alone, or an intraperitoneal injection of the MC4R agonist, LY2112688 (3 mg/kg BW), at time zero. Blood glucose and total GLP-1 (tGLP-1) were measured at the indicated time points. ( A, B) Time course of blood glucose levels during AR231453 stimulus and corresponding AUC analysis. ( C, D) Time course of total tGLP-1 levels during AR231453 stimulus and corresponding AUC analysis. ( E, F) Time course of blood glucose levels during LY2112688 stimulus and corresponding AUC analysis. ( G, H) Time course of total tGLP-1 levels during LY2112688 stimulus and corresponding AUC analysis. For AR231453 studies: Gcg DistalGut+/+ AR231453, n = 14 (males + females); Gcg DistalGut+/+ Vehicle, n = 5 (males + females); Gcg DistalGut−/- AR231453, n = 5 (males + females). For LY2112688 studies: Gcg DistalGut+/+ , n = 19 (males + females); Gcg DistalGut−/- , n = 5 (males + females). Statistical significance was determined using one-way ANOVA (panels B, D) or two-tailed t -test (panels F, H). ∗∗ P < 0.01; ∗∗∗ P < 0.001.

Article Snippet: LY2112688 , Melanocortin-4 receptor (MC4R) peptide agonist , Intraperitoneal , PBS , 3 mg/kg , Bachem (819048-44-7).

Techniques: Expressing, Clinical Proteomics, Injection, Two Tailed Test